Poison is a status effect in Salt and Sanctuary. You can inflict poison on enemies using weapons with poison effects, spells/charms/buffs that inflict poison, or items that inflict poison.

Poison damage is added to a pool that ticks once per second for 20 seconds. Poison must first buildup to break through the target's defenses to deal damage. Damage in the pool technically ticks even when it doesn't deal damage, so the faster the buildup the better. Each hit of additional poison damage will add to the pool's total and also reset the timer to 20 seconds.

Poison damage is doubled when applied to the damage pool. So 18 poison damage is really 36 damage over 20 seconds. Each tick is always 1/20th of the pool.

Each weapon or weapon modifier (charms, buffs) adds a buildup value. The base is 1.0 and each additional is + 0.5. Melee weapons have an innate 0.5 bonus. Mireheart Charm is doubled to 1.0 buildup per hit.
For example, using Pessklaw + Vile Charm + Pessmud would grant a buildup value of 1.0 + 0.5 + 0.5 +0.5 = 2.5 per hit.

Buildup required to trigger damage from poison is given by the formula: buildup > 3 + defense / 20
A monster (or player) with 900 poison defense therefore would require 48 points of buildup to trigger poison damage. Poison damage itself is reduced by defense as well.

The weapons that inherently inflict poison are:

You can add poison to your weapon through:

Poison Arrows, Poison Bolts and Tainted Shots are ammunition that can used to inflict poison damage without an inherent poison weapon.

Wraithfangs and Forestfangs are throwable consumables that inflict poison.

Poison Gas is an incantation that can poison enemies without the use of a weapon. Poison gas has a high buildup due to a multiple hit effect.




Tired of anon posting? Register!
    • Anonymous

      The poison system in this game is quite confusing. I hope this page figured it out correctly, can someone confirm it ?

      I hope this page is right. Because the decorelation between poison buildup and poison damage means that it is actually interesting to play poison weapons, rather than just using wraithfangs. You can use a specific weapon to build poison at a decent pace, I guess a pessklaw with mireheart charm + pessmud, for a buildup of 2.5 per hit according to this page. Then use wraithfang or another poison weapon with high damages to actually deal poison damages.

      I am definitely excited to try this out. In my previous poison run, 6 months ago, I just ended up spaming wraithfangs (yeah, I killed the limb with wraithfang and poison too, you just have to throw a lot of them). The idea of being able to buildup damages quicker if I take some risk is quite appealing. It would bring more variety to poison builds.

      • Clearly this person doesn't really know how poison works. Allow me to explain.
        All enemies have a certain amount of poison resistance, which defines how much poison they need to be inflicted.
        There are different tiers of poison damage.
        When an enemy is poisoned, the game uses the highest tier of poison damage on the target, even applied mid poison.
        For instance, the Poison Gas incantation has the highest poison BUILDUP of any poison inflicting thing, but it has the lowest poison DAMAGE, or DPS.
        The Wraith Fang has a significantly lower poison BUILDUP, but it has the highest poison DPS in the game (along with mossy pessmud and mireheart charm).
        So if you put these two together by casting Poison Gas and throwing a Wraith Fang at the target, you will nearly instantly proc the fastest possible poison damage in the game.
        Poison OP

      Load more
      ⇈ ⇈